This gene encodes a member of the Skp1-Cullin-F-box family of E3 ubiquitin ligases. The encoded protein is reported to bind to the transmembrane receptor interleukin 1 receptor-like 1 and regulate its ubiquitination and degradation. This protein has been linked to the regulation of pulmonary inflammation and psoriasis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]
Function:
Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.
Subunit:
Directly interacts with SKP1 and CUL1 (By similarity).
Similarity:
Contains 1 CXXSLCtype zinc finger.
Contains 1 F-box domain.
Contains 6 LRR (leucine-rich) repeats.
Contains 1 PHD-type zinc finger.
SWISS:
Q6PCT2
Gene ID:
54620
Database links:
Entrez Gene: 54620 Human
Entrez Gene: 233902 Mouse
Entrez Gene: 308999 Rat
GenBank: BC059173 Human
Omim: 609085 Human
SwissProt: Q6PCT2 Human
SwissProt: Q6PB97 Mouse
Unigene: 152149 Human
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