This gene belongs to a family of genes that are expressed in a variety of tumors but not in normal tissues, except for the testis. The sequences of the family members are highly related but differ by scattered nucleotide substitutions. The antigenic peptide YRPRPRRY, which is also encoded by several other family members, is recognized by autologous cytolytic T lymphocytes. Nothing is presently known about the function of this protein. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2010]
Function:
Antigen, recognized on melanoma by autologous cytolytic T-lymphocytes. Completely silent in normal adult tissues, except testis.
Tissue Specificity:
Expressed in a variety of tumor tissues but not in normal tissues, except testis.
Similarity:
Belongs to the GAGE family.
SWISS:
Q13065
Gene ID:
2543
Database links:
Entrez Gene: 2543 Human
Omim: 300594 Human
SwissProt: Q13065 Human
Unigene: 632815 Human
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