This gene encodes GalNAc transferase 7, a member of the GalNAc-transferase family. The enzyme encoded by this gene controls the initiation step of mucin-type O-linked protein glycosylation and transfer of N-acetylgalactosamine to serine and threonine amino acid residues. This enzyme is a type II transmembrane protein and shares common sequence motifs with other family members. Unlike other family members, this enzyme shows exclusive specificity for partially GalNAc-glycosylated acceptor substrates and shows no activity with non-glycosylated peptides. This protein may function as a follow-up enzyme in the initiation step of O-glycosylation. [provided by RefSeq, Jul 2008]
Function:
Glycopeptide transferase involved in O-linked oligosaccharide biosynthesis, which catalyzes the transfer of an N-acetyl-D-galactosamine residue to an already glycosylated peptide. In contrast to other proteins of the family, it does not act as a peptide transferase that transfers GalNAc onto serine or threonine residue on the protein receptor, but instead requires the prior addition of a GalNAc on a peptide before adding additional GalNAc moieties. Some peptide transferase activity is however not excluded, considering that its appropriate peptide substrate may remain unidentified.
Subcellular Location:
Golgi apparatus membrane.
Tissue Specificity:
Widely expressed. Expressed in uterus, retina, kidney, small intestine, omentum, stomach and CNS.
Similarity:
Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
Contains 1 ricin B-type lectin domain.
SWISS:
Q86SF2
Gene ID:
5369
Database links:
Entrez Gene: 5369 Human
Entrez Gene: 108150 Mouse
Entrez Gene: 100171466 Orangutan
Entrez Gene: 29750 Rat
Omim: 605005 Human
SwissProt: Q86SF2 Human
SwissProt: Q80VA0 Mouse
SwissProt: Q5RFJ6 Orangutan
SwissProt: Q9R0C5 Rat
Unigene: 59688 Human
Unigene: 62886 Mouse
Unigene: 201440 Rat
|
|
