The ganglioside GD3 synthase causes cell differentiation with neurite sprouting when transfected into the mouse neuroblastoma cell line Neuro2a. After differentiation, the expression of several genes is upregulated, including one that encodes a protein termed ganglioside-induced differentiation-associated protein 1 (Gdap1). A similar gene was found in humans, and mutations in the human gene are associated with Charcot-Marie-Tooth type 4A disease. The protein encoded by this gene is similar in sequence to the human GDAP1 protein. Several transcript variants encoding different isoforms, as well as a noncoding transcript variant, have been found for this gene. [provided by RefSeq, Feb 2012]
Similarity:
Belongs to the GST superfamily.
Contains 1 GST SLCterminal domain.
Contains 1 GST N-terminal domain.
SWISS:
Q96MZ0
Gene ID:
78997
Database links:
Entrez Gene: 78997 Human
Entrez Gene: 541158 Cow
Entrez Gene: 228858 Mouse
Entrez Gene: 311616 Rat
SwissProt: Q96MZ0 Human
SwissProt: Q8VE33 Mouse
Unigene: 517059 Human
Unigene: 102080 Mouse
|
|
