Rabbit Anti-Germinal Center Kinase antibody

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GC kinase; B lymphocyte serine/threonine protein kinase; B lymphocyte serine/threonine-protein kinase; BL44; GC kinase; GCK; Germinal center kinase; germinal centre kinase (GC kinase); M4K2_HUMAN; MAP4K2; MAPK/ERK kinase kinase kinase 2; MEK kin

Cat:

SL1648R

Species Reactivity：

(predicted: Human,Mouse,Rat,Dog,)

Immunogen：

KLH conjugated synthetic peptide derived from human Germinal Center Kinase:4-100/820

Format：

Liquid

Storage instructions：

Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

ELISA=1:5000-10000IHC-P=1:100-500IHC-F=1:100-500ICC=1:100-500IF=1:100-500（Paraffin sections need to do antigen repair）not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

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Unit:

Price: $228.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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The protein encoded by this gene is a member of the serine/threonine protein kinase family. Although this kinase is found in many tissues, its expression in lymphoid follicles is restricted to the cells of germinal centre, where it may participate in B-cell differentiation. This kinase can be activated by TNF-alpha, and has been shown to specifically activate MAP kinases. This kinase is also found to interact with TNF receptor-associated factor 2 (TRAF2), which is involved in the activation of MAP3K1/MEKK1. [provided by RefSeq, Jul 2008]

Function:
Enhances MAP3K1 oligomerization, which may relieve amino-terminal mediated MAP3K1 autoinhibition and lead to activation following autophosphorylation. May play a role in the regulation of vesicle targeting or fusion.

Subcellular Location:
Cytoplasm. Basolateral cell membrane. Golgi apparatus membrane.

Tissue Specificity:
Highly expressed in germinal center but not mantle zone B-cells. Also expressed in lung, brain and placenta and at lower levels in other tissues examined.

Similarity:
Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family.
STE20 subfamily.
Contains 1 CNH domain. Contains 1 protein kinase domain.

SWISS:
Q12851

Gene ID:
5871

Database links:

Entrez Gene: 5871 Human

Entrez Gene: 26412 Mouse

Omim: 603166 Human

SwissProt: Q12851 Human

SwissProt: Q61161 Mouse

Unigene: 534341 Human

Unigene: 25860 Mouse

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