MRGE is a 311 amino acid multi-pass membrane protein that acts as an orphan receptor and is though to influence nociceptor function. A member of the G-protein coupled receptor 1 family and MAS subfamily, MRGE is encoded by a gene that maps to human chromosome 11p15.4 and mouse chromosome 7 F5. Chromosome 11 comprises approximately 4% of human genomic DNA and is considered a gene and disease association dense chromosome. The chromosome 11 encoded Atm gene is important for regulation of cell cycle arrest and apoptosis following double strand DNA breaks. Atm mutation leads to the disorder known as ataxia-telangiectasia. Jervell and Lange-Nielsen syndrome, Jacobsen syndrome, Niemann-Pick disease, hereditary angioedema and Smith-Lemli-Opitz syndrome are also associated with defects in chromosome 11-encoded genes.
Function:
Orphan receptor. May regulate nociceptor function and/or development, including the sensation or modulation of pain.
Subcellular Location:
Cell membrane.
Similarity:
Belongs to the G-protein coupled receptor 1 family. Mas subfamily.
SWISS:
Q86SM8
Gene ID:
116534
Database links:
Entrez Gene: 116534 Human
Entrez Gene: 244238 Mouse
Entrez Gene: 404660 Rat
Omim: 607232 Human
SwissProt: Q86SM8 Human
SwissProt: Q91ZB7 Mouse
SwissProt: Q7TN40 Rat
Unigene: 706565 Human
Unigene: 183561 Mouse
Unigene: 189891 Rat
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