This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. It is specifically expressed in the retina and the encoded protein has been shown to phosphorylate cone opsins and initiate their deactivation. [provided by RefSeq, Jul 2008]
Function:
Phosphorylates cone opsins thereby initiating their deactivation.
Subcellular Location:
Membrane.
Tissue Specificity:
Retina. Cones and rod.
Similarity:
Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.
GPRK subfamily.
Contains 1 AGSLCkinase SLCterminal domain.
Contains 1 protein kinase domain.
Contains 1 RGS domain.
SWISS:
Q8WTQ7
Gene ID:
131890
Database links:
Entrez Gene: 131890 Human
Omim: 606987 Human
SwissProt: Q8WTQ7 Human
Unigene: 136654 Human
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