The human glucocorticoid receptor DNA binding factor, which associates with the promoter region of the glucocorticoid receptor gene (hGR gene), is a repressor of glucocorticoid receptor transcription. The amino acid sequence deduced from the cDNA sequences show the presence of three sequence motifs characteristic of a zinc finger and one motif suggestive of a leucine zipper in which 1 cysteine is found instead of all leucines. The GRLF1 enhances the homologous down-regulation of wild-type hGR gene expression. Biochemical analysis suggests that GRLF1 interaction is sequence specific and that transcriptional efficacy of GRLF1 is regulated through its interaction with specific sequence motif. The level of expression is regulated by glucocorticoids. [provided by RefSeq, Jul 2008]
Function:
Represses transcription of the glucocorticoid receptor by binding to the cis-acting regulatory sequence 5'-GAGAAAAGAAACTGGAGAAACTSLC3'. May participate in the regulation of retinal development and degeneration. May transduce signals from p21-ras to the nucleus, acting via the ras GTPase-activating protein (GAP). May also act as a tumor suppressor.
Subcellular Location:
Cytoplasm. Nucleus.
Post-translational modifications:
Tyrosine phosphorylated.
Phosphorylated upon DNA damage, probably by ATM or ATR.
Similarity:
Contains 4 FF domains.
Contains 1 Rho-GAP domain.
SWISS:
Q9NRY4
Gene ID:
2909
Database links:
Entrez Gene: 2909 Human
Entrez Gene: 232906 Mouse
Entrez Gene: 301280 Rat
Omim: 605277 Human
SwissProt: Q9NRY4 Human
SwissProt: Q91YM2 Mouse
SwissProt: P81128 Rat
Unigene: 509447 Human
Unigene: 28646 Mouse
Unigene: 400358 Mouse
Unigene: 16508 Rat
Unigene: 222475 Rat
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