GRRP1 (glycine/arginine-rich protein 1), also known as FAM110D, is a 271 amino acid protein encoded by a gene that maps to human chromosome 1p36.11 and mouse chromosome 4 D3. Chromosome 1 is the largest human chromosome spanning about 260 million base pairs and making up 8% of the human genome. There are about 3,000 genes on chromosome 1, and considering the great number of genes, there are also a large number of diseases associated with chromosome 1. Notably, the rare aging disease Hutchinson-Gilford progeria is associated with the LMNA gene which encodes lamin A. When defective, the LMNA gene product can build up in the nucleus and cause characteristic nuclear blebs. The mechanism of rapidly enhanced aging is unclear and is a topic of continuing exploration. The MUTYH gene is located on chromosome 1 and is partially responsible for familial adenomatous polyposis. Stickler syndrome, Parkinsons, Gaucher disease and Usher syndrome are also associated with chromosome 1.
Similarity:
Belongs to the FAM110 family.
SWISS:
Q8TAY7
Gene ID:
79927
Database links:
Entrez Gene: 79927 Human
Entrez Gene: 72690 Mouse
Entrez Gene: 500563 Rat
SwissProt: Q8TAY7 Human
SwissProt: Q80X91 Mouse
Unigene: 694119 Human
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