Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-transferase that belongs to the mu class. The mu class of enzymes functions in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione. The genes encoding the mu class of enzymes are organized in a gene cluster on chromosome 1p13.3 and are known to be highly polymorphic. These genetic variations can change an individual's susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of certain drugs. [provided by RefSeq, Jul 2008]
Function:
Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.
Subcellular Location:
Cytoplasm.
Tissue Specificity:
Muscle.
Similarity:
Belongs to the GST superfamily. Mu family.
Contains 1 GST SLCterminal domain.
Contains 1 GST N-terminal domain.
SWISS:
P28161
Gene ID:
2946
Database links:
Entrez Gene: 2946 Human
Entrez Gene: 14863 Mouse
Entrez Gene: 24424 Rat
Omim: 138380 Human
SwissProt: P28161 Human
SwissProt: P15626 Mouse
SwissProt: P08010 Rat
Unigene: 279837 Human
Unigene: 88086 Mouse
Unigene: 625 Rat
|
|
