Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-transferase that belongs to the mu class. The mu class of enzymes functions in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione. The genes encoding the mu class of enzymes are organized in a gene cluster on chromosome 1p13.3 and are known to be highly polymorphic. These genetic variations can change an individual's susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of certain drugs. Diversification of these genes has occurred in regions encoding substrate-binding domains, as well as in tissue expression patterns, to accommodate an increasing number of foreign compounds. [provided by RefSeq, Jul 2008]
Function:
Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.
Subcellular Location:
Cytoplasm.
Similarity:
Belongs to the GST superfamily. Mu family.
Contains 1 GST SLCterminal domain.
Contains 1 GST N-terminal domain.
SWISS:
P46439
Gene ID:
2949
Database links:
Entrez Gene: 2949 Human
Entrez Gene: 14866 Mouse
Entrez Gene: 64352 Rat
Omim: 138385 Human
SwissProt: P46439 Human
SwissProt: P48774 Mouse
SwissProt: Q9Z1B2 Rat
Unigene: 75652 Human
Unigene: 282351 Mouse
Unigene: 9158 Rat
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