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Rabbit Anti-GTF2F1 antibody
In eukaryotic systems, initiation of transcription from protein-coding genes is a complex process requiring RNA polymerase II and broad families of auxiliary transcription factors. Such factors can be divided into two major functional classes: the basal factors that are required for transcription of all Pol II genes, including TFIIA, TFIIB, TFIID, TFIIE, TFIIF and TFIIH; and sequence-specific factors that regulate gene expression. The basal transcription factors and Pol II form a specific multiprotein complex near the transcription start site by interacting with core promotor elements such as the TATA box generally located 25-30 base pairs upstream of the transcription start site. TFIIF, a heteromer composed of a small (RAP 30) and a large (RAP 74) subunit, is required for RNA polymerase II to assemble into a preinitiation complex formed by promotor DNA and the general factors TFIID, IIA and IIB. In addition, TFIIF stimulates transcription elongation by RNA polymerase II.
Function:
TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation.
Subcellular Location:
Nucleus.
Post-translational modifications:
Phosphorylated on Ser and other residues by TAF1 and casein kinase II-like kinases.
Similarity:
Belongs to the TFIIF alpha subunit family.
SWISS:
P35269
Gene ID:
2962
Database links:
Entrez Gene: 2962 Human
Entrez Gene: 19653 Mouse
Entrez Gene: 316123 Rat
Omim: 89968 Human
SwissProt: P35269 Human
SwissProt: Q3THK3 Mouse
SwissProt: Q6AY96 Rat
Unigene: 68257 Human
Unigene: 24632 Mouse
Unigene: 98836 Rat
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