C6ORF55 encodes a protein involved in trafficking of the multivesicular body, an endosomal compartment involved in sorting membrane proteins for degradation in lysosomes (Ward et al., 2005 [PubMed 1564464]).[supplied by OMIM, Mar 2008]
Function:
Involved in the endosomal multivesicular bodies (MVB) pathway. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. Thought to be a cofactor of VPS4A/B, which catalyzes disassembles membrane-associated ESCRT-III assemblies. Involved in the sorting and down-regulation of EGFR. Involved in HISLV1 budding.
Subunit:
Interacts with VPS4B. Interacts with CHMP1B. Interacts with CHMP2A; the interaction probably involves the open conformation of (polymerized) CHMP2A. Interacts with CHMP3. Interacts with CHMP5; the interaction involves soluble CHMP5. Interacts with IST1.
Subcellular Location:
Cytoplasm. Endosome membrane; Peripheral membrane protein (Probable).
Similarity:
Belongs to the VTA1 family.
SWISS:
Q9NP79
Gene ID:
51534
Database links:
Entrez Gene: 506430 Cow
Entrez Gene: 51534 Human
Entrez Gene: 66201 Mouse
Entrez Gene: 292128 Rat
GenBank: BC005937 Human
Omim: 610902 Human
SwissProt: Q32L63 Cow
SwissProt: Q9NP79 Human
SwissProt: Q9CR26 Mouse
Unigene: 431367 Human
Unigene: 227983 Mouse
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