This gene encodes a member of the TFB4 family. The encoded protein is a subunit of the core-TFIIH basal transcription factor and localizes to the nucleus. The encoded protein is involved in RNA transcription by RNA polymerase II and nucleotide excision repair and associates with the Cdk-activating kinase complex. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 14. [provided by RefSeq, Dec 2012]
Function:
Component of the core-TFIIH basal transcription factor involved in nucleotide excision repair (NER) of DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. Anchors XPB.
Subcellular Location:
Nucleus.
Similarity:
Belongs to the TFB4 family.
SWISS:
Q13889
Gene ID:
2967
Database links:
Entrez Gene: 2967 Human
Entrez Gene: 511896 Cow
Entrez Gene: 100059174 Horse
Entrez Gene: 209357 Mouse
Entrez Gene: 288651 Rat
Omim: 601750 Human
SwissProt: Q05B56 Cow
SwissProt: Q13889 Human
SwissProt: Q8VD76 Mouse
SwissProt: Q561R7 Rat
Unigene: 355348 Human
Unigene: 185467 Mouse
Unigene: 203542 Rat
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