Initiation of transcription from protein-coding genes in eukaryotes is a complex process that requires RNA polymerase II, as well as families of basal transcription factors. Binding of the factor TFIID (TBP) to the TATA box is believed to be the first step in the formation of a multiprotein complex containing several additional factors, including TFIIA, TFIIB, TFIIE, TFIIF and TFIIH. TFIIH (or BTF2) is a multisubunit transcription/DNA repair factor that possesses several enzymatic activities. The core of TFIIH is composed of 5 subunits, designated p89 (XPB or ERCC3), p62, p52, p44 and p34. Additional subunits of the TFIIH complex are p80 (XPD or ERCC2) and the ternary kinase complex composed of Cdk7, cyclin H and MAT1. Both p89 and p80 have ATP-dependent helicase activity. The p62, p52 and p44 subunits have been shown to be involved in nucleotide excision repair.
Function:
Component of the core-TFIIH basal transcription factor involved in nucleotide excision repair (NER) of DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II.
Subcellular Location:
Nucleus.
Similarity:
Belongs to the TFB2 family.
SWISS:
Q92759
Gene ID:
2968
Database links:
Entrez Gene: 2968 Human
Entrez Gene: 462549 Chimpanzee
Entrez Gene: 100137723 Cow
Entrez Gene: 14885 Mouse
Entrez Gene: 100144458 Pig
Entrez Gene: 294236 Rat
Omim: 601760 Human
SwissProt: P60027 Chimpanzee
SwissProt: Q92759 Human
SwissProt: O70422 Mouse
Unigene: 485070 Human
Unigene: 10182 Mouse
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