The product of this gene is a zinc finger protein with nine Cis[2]-His[2] zinc finger domains. It functions as an RNA polymerase III transcription factor to induce transcription of the 5S rRNA genes. The protein binds to a 50 bp internal promoter in the 5S genes called the internal control region (ICR), and nucleates formation of a stable preinitiation complex. This complex recruits the TFIIIC and TFIIIB transcription factors and RNA polymerase III to form the complete transcription complex. The protein is thought to be translated using a non-AUG translation initiation site in mammals based on sequence analysis, protein homology, and the size of the purified protein. [provided by RefSeq, Jul 2008]
Function:
Interacts with the internal control region (ICR) of approximately 50 bases within the 5S RNA genes, is required for correct transcription of these genes by RNA polymerase III. Also binds the transcribed 5S RNA's. May initiate transcription of the 5S ribosomal RNA gene and maintain the stability of transcription of other genes.
Subcellular Location:
Nucleus.
Tissue Specificity:
Ubiquitous.
Similarity:
Contains 9 C2H2-type zinc fingers.
SWISS:
Q92664
Gene ID:
2971
Database links:
Entrez Gene: 2971 Human
Entrez Gene: 66596 Mouse
Entrez Gene: 246299 Rat
Omim: 600860 Human
SwissProt: Q92664 Human
SwissProt: Q8VHT7 Mouse
SwissProt: Q8VHT8 Rat
Unigene: 445977 Human
Unigene: 358698 Mouse
Unigene: 195324 Rat
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