This gene encodes a member of the trinucleotide repeat containing 6 protein family. The protein functions in post-transcriptional gene silencing through the RNA interference (RNAi) and microRNA pathways. The protein associates with messenger RNAs and Argonaute proteins in cytoplasmic bodies known as GW-bodies or P-bodies. Inhibiting expression of this gene delocalizes other GW-body proteins and impairs RNAi and microRNA-induced gene silencing. [provided by RefSeq, Jul 2008]
Function:
Plays a role in RNA-mediated gene silencing by both micro-RNAs (miRNAs) and short interfering RNAs (siRNAs). Required for miRNA-dependent repression of translation and for siRNA-dependent endonucleolytic cleavage of complementary mRNAs by argonaute family proteins.
Subcellular Location:
Cytoplasm > P-body. Mammalian P-bodies are also known as GW bodies.
Tissue Specificity:
Ubiquitous.
Similarity:
Belongs to the GW182 family.
Contains 1 RRM (RNA recognition motif) domain.
SWISS:
Q8NDV7
Gene ID:
27327
Database links:
Entrez Gene: 27327 Human
Entrez Gene: 233833 Mouse
Entrez Gene: 308971 Rat
Omim: 610739 Human
SwissProt: Q8NDV7 Human
SwissProt: Q3UHK8 Mouse
Unigene: 407740 Human
Unigene: 655057 Human
Unigene: 102305 Mouse
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