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Rabbit Anti-ARHGAP45 antibody
Major histocompatibility complex (MHC) molecules, which include human leukocyte antigens (HLAs), form an integral part of the immune response system. They are cell-surface receptors that bind foreign peptides and present them to cytotoxic T lymphocytes (CTLs). Minor histocompatibility antigens can form an immune response upon recognition by certain T-cells when complexed with MHC molecules. HA-1 (minor histocompatibility protein HA-1), also known as HA-1, HLA-HA1 or HMHA1, is a 1,136 amino acid GTPase activator of Rho-type GTPases. Expressed in dendritic cells, epidermal Langerhans cells, hematopoietic cells, peripheral blood mononuclear cells and all leukemia and lymphoma cell lines, HA-1 is also found in various solid tissues and tumors. Highly phosphorylated, HA-1 contains one Rho-GAP domain, a single phorbol-ester/DAG-type zinc finger and is encoded by a gene located on human chromosome 19p13.3.
Function:
The minor histocompatibility antigen (mHags), HA-1 is a immunogenic alloantigen shown to be responsible for graft-versus-host disease (GVHD) in HLA-identical bone marrow transplantation. The antigen has two known alleles resulting in a single amino acid polymorphism. The HA-1H allele encodes histidine, whereas the HA-1R allele encodes arginine.
Subunit:
HA-1 forms a complex with MHC class I HLA-A*0201.
Subcellular Location:
Cytoplasmic
Tissue Specificity:
Expressed on cells of the hematopoietic lineage. Detected in dendritic cells and epidermal Langerhans cells. Expressed in peripheral blood mononuclear cells, in all leukemia/lymphoma cell lines. Detected also in some solid tumors and tissues such as cancerous and non-cancerous tissue
Similarity:
Contains 1 phorbol-ester/DAG-type zinc finger.
Contains 1 Rho-GAP domain.
SWISS:
Q92619
Gene ID:
23526
Database links:
Entrez Gene: 23526 Human
Entrez Gene: 70719 Mouse
Entrez Gene: 314618 Rat
Omim: 601155 Human
SwissProt: Q92619 Human
SwissProt: Q3TBD2 Mouse
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