Zinc finger X-linked duplicated family member C (ZXDC) is an 858 amino acid protein belonging to the ZDX family. Localized to the nucleus, ZDXC is expressed at high levels in heart, kidney, liver and testis, with lower levels of expression in lung, muscle, placenta, small intestine and spleen. ZDXC, with ZDXA, forms a complex that binds to the class II trans-activator (CIITA). CIITA, like the X1-binding regulatory factor X (RFX) complex and the nuclear factor Y (NFY) complex, is a transcriptional co-factor that is necessary, but not sufficient, for major histocompatibility complex (MHC) class II gene transcription. ZXDC, by regulating CIITA function, activates the transcription of MHC genes.
Function:
Cooperates with CIITA to promote transcription of MHC class I and MHC class II genes.
Subcellular Location:
Nucleus.
Tissue Specificity:
Expressed at high levels in heart, kidney, liver and testis, at moderate levels in brain and stomach, and at low levels in lung, muscle, placenta, small intestine and spleen.
Similarity:
Belongs to the ZXD family.
Contains 10 C2H2-type zinc fingers.
SWISS:
Q2QGD7
Gene ID:
79364
Database links:
Entrez Gene: 79364 Human
Entrez Gene: 80292 Mouse
Entrez Gene: 362399 Rat
SwissProt: Q2QGD7 Human
SwissProt: Q8C8V1 Mouse
Unigene: 88049 Human
Unigene: 711046 Human
Unigene: 100116 Mouse
Unigene: 473652 Mouse
|
|
