Rabbit Anti-ZRANB2/ZNF265 antibody

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ZRANB 2; DKFZp686J1831; DKFZp686N09117; FLJ41119; ZSC23_HUMAN OTTHUMP00000011240; OTTHUMP00000011241; Zinc finger protein 265; Zinc finger RAN binding domain containing 2; Zinc finger Ran binding domain containing protein 2; Zinc finger splicing;

Cat:

SL11286R

Species Reactivity：

(predicted: Human,Mouse,Rat,Cow,Horse,Sheep,)

Immunogen：

KLH conjugated synthetic peptide derived from human ZRANB2/ZNF265:251-330/330

Format：

Liquid

Storage instructions：

Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

WB=1:500-2000ELISA=1:5000-10000IHC-P=1:100-500IHC-F=1:100-500ICC=1:100-500IF=1:100-500（Paraffin sections need to do antigen repair）not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

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Unit:

Price: $228.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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Zinc-finger proteins contain DNA-binding domains and have a wide variety of functions, most of which encompass some form of transcriptional activation or repression. ZNF265 (Zinc finger protein 265), also known as ZRANB2 (Zinc finger Ran-binding domain-containing protein 2), ZIS, ZIS1 or ZIS2, is a 330 amino acid protein that belongs to the ZRANB2 family. Localized to the nucleus, ZNF265 functions as a splicing factor that is responsible for alternatively splicing Tra-2∫ (transformer-2 beta) transcripts and is thought to interfere with constitutive 5’-splice selection. ZNF265 contains two RanBP2-type zinc fingers through which it conveys its RNA-binding activity. Two isoforms, designated ZIS-1 and ZIS-2, are expressed due to alternative splicing events. Upon DNA damage, ZIS-2 may be phosphorylated by ATM or ATR.

Function:
ZRANB2 is a splice factor required for alternative splicing of SFRS10/TRA2B transcripts. It may interfere with constitutive 5'-splice site selection.

Subunit:
Interacts with the SLCterminal half of SNRNP70, the Arg/Ser-rich domain of AKAP17A as well as with U2AF1 and CLK1.

Subcellular Location:
Nuclear

Post-translational modifications:
Isoform 2 is phosphorylated on Ser-310 upon DNA damage, probably by ATM or ATR.

Similarity:
Belongs to the ZRANB2 family.
Contains 2 RanBP2-type zinc fingers.

SWISS:
O95218

Gene ID:
9406

Database links:

Entrez Gene: 9406 Human

Entrez Gene: 53861 Mouse

Entrez Gene: 58821 Rat

Omim: 604347 Human

SwissProt: O95218 Human

SwissProt: Q9R020 Mouse

SwissProt: O35986 Rat

Unigene: 194718 Human

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