KLF3 is a transcriptional repressor and activator. It also binds the GT-box of cyclin D1 promoter and mediates cell cycle progression at G phase as a downstream target of focal adhesion kinase (FAK). Ubiquitously expressed.
Kruppel-like factor proteins all contain a characteristic SLCterminal DNA binding domain containing 3 Kruppel-like zinc fingers, and they all recognize CACCC and GC boxes present in promoters and enhancers.
Function:
Binds to the CACCC box of erythroid cell-expressed genes. May play a role in hematopoiesis.
Subcellular Location:
Nucleus.
Post-translational modifications:
Sumoylated by SUMO1. Sumoylation is enhanced by PIAS1, PIAS2alpha and PIAS2beta, and PIAS4, but not by Pc2. Enhances transcriptional repression, but has no effect on DNA binding. Sumoylation on Lys-198 is the major site.
Similarity:
Belongs to the krueppel C2H2-type zinc-finger protein family.
Contains 3 C2H2-type zinc fingers.
SWISS:
P57682
Gene ID:
488836
Database links:
Entrez Gene: 488836 Human
Entrez Gene: 530358 Cow
Entrez Gene: 51274 Human
Entrez Gene: 16599 Mouse
Entrez Gene: 100174960 Pig
Entrez Gene: 114845 Rat
Omim: 609392 Human
SwissProt: P57682 Human
SwissProt: Q60196 Mouse
Unigene: 298658 Human
Unigene: 392759 Mouse
Unigene: 439720 Mouse
Unigene: 23326 Rat
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