Zinc functions as a cofactor for numerous enzymes, nuclear factors, and hormones and as an intra- and intercellular signal ion. Members of the zinc transporter (ZNT)/SLC30 subfamily of the cation diffusion facilitator family, such as SLC30A6, permit cellular efflux of zinc (Seve et al., 2004 [PubMed 15154973]).[supplied by OMIM, Mar 2008]
Function:
Zinc-efflux transporter which allocates the cytoplasmic zinc to the trans-Golgi network (TGN) as well as the vesicular compartment.
Subcellular Location:
Golgi apparatus > trans-Golgi network membrane. Found in vesicules.
Tissue Specificity:
Expressed in brain; especially in cerebellum, hippocampus, parahippocampal gyrus, superior and middle temporal gyrus. Also expressed in B cells, colon, eye, and lung. Lower expression was present in bone, brain, cervix, ear, heart, kidney, muscle, nerve, pancreas, prostate, skin, stomach, and testis.
Similarity:
Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4)
family. SLC30A subfamily.
SWISS:
Q6NXT4
Gene ID:
55676
Database links:
Entrez Gene: 55676 Human
Entrez Gene: 210148 Mouse
Omim: 611148 Human
SwissProt: Q6NXT4 Human
SwissProt: Q8BJM5 Mouse
Unigene: 23248 Human
Unigene: 243943 Mouse
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