Members of the Ikaros (ZNFN1A1; MIM 603023) family of transcription factors, which includes Eos, are expressed in lymphocytes and are implicated in the control of lymphoid development.[supplied by OMIM, Jul 2002]
Function:
DNA-binding protein that binds to the 5'GGGAATRCSLC3' Ikaros-binding sequence. Transcriptional repressor. Interacts with SPI1 and MITF to repress transcription of the CTSK and ACP5 promoters via recruitment of corepressors SIN3A and CTBP2. May be involved in the development of central and peripheral nervous systems.
Subcellular Location:
Nucleus.
Tissue Specificity:
Highly expressed in skeletal muscle, low levels of expression in heart, thymus, kidney, liver, and spleen. Expressed in the hematopoietic cell lines MOLT-4, NALM-6 and K562. Highly expressed in THP-1 and Mo7e-IL3 cell lines, which have characteristics of myeloid and early megakaryocytic cells respectively.
Similarity:
Belongs to the Ikaros C2H2-type zinc-finger protein family.
Contains 6 C2H2-type zinc fingers.
SWISS:
Q9H2S9
Gene ID:
64375
Database links:
Entrez Gene: 64375 Human
Entrez Gene: 22781 Mouse
Entrez Gene: 100361923 Rat
Omim: 606239 Human
SwissProt: Q9H2S9 Human
SwissProt: Q8C208 Mouse
Unigene: 553221 Human
Unigene: 358648 Mouse
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