Zinc-finger proteins contain DNA-binding domains and have a wide variety of functions, most of which encompass some form of transcriptional activation or repression. The majority of zinc-finger proteins contain a Krüppel-type DNA binding domain and a KRAB domain, which is thought to interact with KAP1, thereby recruiting histone modifying proteins. ZNF98 (zinc finger protein 98) and ZNF492 (zinc finger protein 492) are zinc finger proteins belonging to the Krüppel C2H2-type zinc-finger protein family. Both ZNF98 and ZNF492 localize to the nucleus and contain thirteen C2H2-type zinc fingers and a KRAB domain. ZNF98 and ZNF492 may play a role in transcriptional regulation.
Function:
May be involved in transcriptional regulation.
Subcellular Location:
Nucleus.
Similarity:
Belongs to the krueppel C2H2-type zinc-finger protein family.
Contains 13 C2H2-type zinc fingers.
Contains 1 KRAB domain.
SWISS:
A6NK75
Gene ID:
148198
Database links:
Entrez Gene: 148198 Human
Omim: 60796 Human
SwissProt: A6NK75 Human
Unigene: 667355 Human
|
|
