ZNF827 (zinc finger protein 827) is a 1,081 amino acid nuclear protein that contains nine C2H2-type zinc fingers and belongs to the krueppel C2H2-type zinc-finger protein family. Existing as three alternatively spliced isoforms, ZNF827 may be involved in transcriptional regulation. The gene that encodes ZNF827 consists of around 181,000 bases and maps to human chromosome 4q31.2. Chromosome 4 represents approximately 6% of the human genome and contains nearly 900 genes. Notably, the Huntingtin gene, which is found to encode an expanded glutamine tract in cases of Huntington's disease, is encoded by a gene that maps to chromosome 4. FGFR-3 is also encoded by a gene located on chromosome 4 and has been associated with thanatophoric dwarfism, achondroplasia, Muenke syndrome and bladder cancer. Chromosome 4 is also tied to Ellis-van Creveld syndrome, methylmalonic acidemia and polycystic kidney disease.
Function:
May be involved in transcriptional regulation.
Subcellular Location:
Nucleus.
Similarity:
Belongs to the krueppel C2H2-type zinc-finger protein family.
Contains 9 C2H2-type zinc fingers.
SWISS:
Q17R98
Gene ID:
152485
Database links:
Entrez Gene: 152485 Human
Entrez Gene: 622675 Mouse
SwissProt: Q17R98 Human
SwissProt: Q505G8 Mouse
Unigene: 133916 Human
Unigene: 48724 Mouse
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