Zinc-finger proteins contain DNA-binding domains and have a wide variety of functions, most of which encompass some form of transcriptional activation or repression. The majority of zinc-finger proteins contain a Krüppel-type DNA binding domain and a KRAB domain, which is thought to interact with KAP1, thereby recruiting histone modifying proteins. Zinc finger protein 768 (ZNF768) is a 540 amino acid member of the Krüppel C2H2-type zinc-finger protein family. Localized to the nucleus, ZNF768 contains ten C2H2-type zinc fingers through which it is thought to be involved in DNA-binding and transcriptional regulation.
Function:
May be involved in transcriptional regulation.
Subcellular Location:
Nucleus.
Post-translational modifications:
Phosphorylated upon DNA damage, probably by ATM or ATR.
Similarity:
Belongs to the krueppel C2H2-type zinc-finger protein family.
Contains 10 C2H2-type zinc fingers.
SWISS:
Q9H5H4
Gene ID:
79724
Database links:
Entrez Gene: 79724 Human
Entrez Gene: 233890 Mouse
SwissProt: Q9H5H4 Human
SwissProt: Q8R0T2 Mouse
Unigene: 85658 Human
Unigene: 23031 Mouse
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