Histidine triad proteins, such as HINT2, are nucleotide hydrolases and transferases that act on the alpha-phosphate of ribonucleotides (Brenner, 2002 [PubMed 12119013]).[supplied by OMIM, Mar 2008]
Function:
Hydrolase probably involved in steroid biosynthesis. May play a role in apoptosis. Has adenosine phosphoramidase activity.
Subcellular Location:
Mitochondrion.
Tissue Specificity:
High expression in liver and pancreas. Expression is significantly down-regulated in hepatocellular carcinoma (HCC) patients.
Similarity:
Belongs to the HINT family.
Contains 1 HIT domain.
SWISS:
Q9BX68
Gene ID:
84681
Database links:
Entrez Gene: 84681 Human
Entrez Gene: 68917 Mouse
Entrez Gene: 313491 Rat
Omim: 609997 Human
SwissProt: Q9BX68 Human
SwissProt: Q9D0S9 Mouse
Unigene: 70573 Human
Unigene: 25285 Mouse
Unigene: 11657 Rat
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