Zinc-finger proteins contain DNA-binding domains and have a wide variety of functions, most of which encompass some form of transcriptional activation or repression. The majority of zinc-finger proteins contain a Krüppel-type DNA binding domain and a KRAB domain, which is thought to interact with KAP1, thereby recruiting histone modifying proteins. Zinc finger protein 688 (ZNF688) is a 276 amino acid member of the Krüppel C2H2-type zinc-finger protein family. Localized to the nucleus, ZNF688 contains two C2H2-type zinc fingers and one KRAB domain through which it is thought to be involved in DNA-binding and transcriptional regulation.
Function:
May be involved in transcriptional regulation.
Subcellular Location:
Nucleus.
Similarity:
Belongs to the krueppel C2H2-type zinc-finger protein family.
Contains 2 C2H2-type zinc fingers.
Contains 1 KRAB domain.
SWISS:
P0C7X2
Gene ID:
146542
Database links:
Entrez Gene: 146542 Human
GenBank: NM_145271 Human
GenBank: NP_660314 Human
SwissProt: P0C7X2 Human
Unigene: 301463 Human
Unigene: 513509 Human
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