Zinc-finger proteins contain DNA-binding domains and have a wide variety of functions, most of which encompass some form of transcriptional activation or repression. The majority of zinc-finger proteins contain a Krüppel-type DNA binding domain and a KRAB domain, which is thought to interact with KAP1, thereby recruiting histone modifying proteins. ZFOC1, also known as ZNF644 (zinc finger protein 644), ZEP2 (zinc finger motif enhancer-binding protein 2) or BM-005, is a 1,327 amino acid nuclear protein belonging to the Krüeppel C2H2-type zinc-finger protein family. Existing as three alternatively spliced isoforms, ZFOC is involved in transcriptional regulation and contains seven C2H2-type zinc fingers. The gene encoding ZFOC1 maps to human chromosome 12q24.31.
Function:
May be involved in transcriptional regulation.
Subcellular Location:
Nucleus.
Similarity:
Belongs to the krueppel C2H2-type zinc-finger protein family.
Contains 9 C2H2-type zinc fingers.
SWISS:
Q8N3J9
Gene ID:
144348
Database links:
Entrez Gene: 144348 Human
Entrez Gene: 269704 Mouse
SwissProt: Q8N3J9 Human
SwissProt: Q4VA44 Mouse
Unigene: 524828 Human
Unigene: 138617 Mouse
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