Rabbit Anti-HSD17B14 antibody

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17 beta hydroxysteroid dehydrogenase 14; 17 beta hydroxysteroid dehydrogenase DHRS10; Dehydrogenase/reductase SDR family member 10; DHRS10; DHB14_HUMAN; Retinal short chain dehydrogenase/reductase 3; Retinal short chain dehydrogenase/reductase retSDR

Cat:

SL16527R

Species Reactivity：

(predicted: Human,Mouse,Rat,Dog,Pig,Cow,Horse,Sheep,)

Immunogen：

KLH conjugated synthetic peptide derived from human HSD17B14:101-200/270

Format：

Liquid

Storage instructions：

Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

ELISA=1:5000-10000IHC-P=1:100-500IHC-F=1:100-500ICC=1:100-500IF=1:100-500（Paraffin sections need to do antigen repair）not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

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Unit:

Price: $228.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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17-beta-hydroxysteroid dehydrogenases, such as HSD17B14, are primarily involved in metabolism of steroids at the C17 position and also of other substrates, such as fatty acids, prostaglandins, and xenobiotics (Lukacik et al., 2007 [PubMed 17067289]).[supplied by OMIM, Jun 2009]

Function:
HSD17B14 belongs to the short-chain dehydrogenases/reductases (SDR) family. It has NAD-dependent 17-beta-hydroxysteroid dehydrogenase activity and converts oestradiol to oestrone. The physiological substrate is not known. HSD17B14 acts on oestradiol and 5-androstene-3-beta,17-beta-diol (in vitro). It is highly expressed in brain, placenta, liver and kidney.

Subunit:
Homotetramer.

Subcellular Location:
Cytoplasmic

Tissue Specificity:
Highly expressed in brain, placenta, liver and kidney.

Similarity:
Belongs to the short-chain dehydrogenases/reductases (SDR) family.

SWISS:
Q9BPX1

Gene ID:
51171

Database links:

Entrez Gene: 51171 Human

Omim: 612832 Human

SwissProt: Q9BPX1 Human

Unigene: 18788 Human

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