This gene encodes a member of the heat shock factor (HSF) family of transcriptional activators for heat shock proteins. This gene is a candidate gene for azoospermia, since it localizes to a region of chromosome Y that is sometimes deleted in infertile males. The genome has two identical copies of this gene within a palindromic region; this record represents the more telomeric copy. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]
Subcellular Location:
Nucleus. Cytoplasm.
Tissue Specificity:
Testis-specific. Present in Sertoli cells and spermatogenic cells (at protein level).
Similarity:
Belongs to the HSF family.
SWISS:
Q96LI6
Gene ID:
159119
Database links:
Entrez Gene: 159119 Human
Entrez Gene: 86614 Human
Omim: 80029 Human
SwissProt: Q96LI6 Human
Unigene: 592255 Human
Unigene: 662281 Human
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