TRAM2 is a component of the translocon, a gated macromolecular channel that controls the posttranslational processing of nascent secretory and membrane proteins at the endoplasmic reticulum (ER) membrane.[supplied by OMIM, Jul 2004]
Function:
Necessary for collagen type I synthesis. May couple the activity of the ER Ca(2+) pump SERCA2B with the activity of the translocon. This coupling may increase the local Ca(2+) concentration at the site of collagen synthesis, and a high Ca(2+) concentration may be necessary for the function of molecular chaperones involved in collagen folding.
Subcellular Location:
Membrane.
Similarity:
Belongs to the TRAM family.
Contains 1 TLC (TRAM/LAG1/CLN8) domain.
SWISS:
Q15035
Gene ID:
9697
Database links:
Entrez Gene: 9697 Human
Entrez Gene: 617287 Cow
Entrez Gene: 474936 Dog
Entrez Gene: 100730382 Guinea pig
Entrez Gene: 100069225 Horse
Entrez Gene: 170829 Mouse
Entrez Gene: 100157796 Pig
Entrez Gene: 301296 Rat
Entrez Gene: 406344 Zebrafish
Omim: 608485 Human
SwissProt: Q15035 Human
SwissProt: Q924Z5 Mouse
Unigene: 520182 Human
Unigene: 185136 Mouse
Unigene: 273241 Mouse
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