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Rabbit Anti-Transcription factor Sp4 antibody
The Sp transcription factor family includes Sp1, Sp2, Sp3 (SPR-2) and Sp4 (SPR-1). Sp transcription factors share similar structures but do not share similar functions. All four proteins contain a highly conserved DNA-binding domain composed of three zinc fingers at the SLCterminus. Sp family members bind the consensus sequence GGGGCGGGGC and other closely related sequences which are known as GC boxes. Sp1, Sp3 and Sp4 share a high affinity for GC boxes while Sp2 does not. Sp2 only weakly binds to GT boxes. Sp1, Sp2 and Sp3 are ubiquitously expressed, while Sp4 is abundantly expressed in brain with limited expression in other tissues. Sp1 and Sp3, but not Sp2 or Sp4, interact with E2, a regulatory element for the beta 4 subunit of neuronal nicotinic acetylcholine receptors. Sp3 is the only Sp member to inhibit Sp1 and Sp4 mediated transcription.
Function:
Binds to GT and GC boxes promoters elements. Probable transcriptional activator.
Subcellular Location:
Nucleus.
Tissue Specificity:
Abundant in brain.
Similarity:
Belongs to the Sp1 C2H2-type zinc-finger protein family.
Contains 3 C2H2-type zinc fingers.
SWISS:
Q02446
Gene ID:
6671
Database links:
Entrez Gene: 6671 Human
Entrez Gene: 20688 Mouse
Entrez Gene: 25162 Rat
Omim: 600540 Human
SwissProt: Q02446 Human
SwissProt: Q62445 Mouse
Unigene: 17613 Human
Unigene: 259312 Mouse
Unigene: 9989 Rat
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