Home
>
Product
>
Antibody
>
Rabbit Anti-Transglutaminase 4 antibody
Terminally differentiating mammalian epidermal cells acquire an insoluble, 10 to 20 nm thick protein deposit on the intracellular surface of the plasma membrane known as the cross-linked cell envelope (CE). The CE is a component of the epidermis that is generated through formation of disulfide bonds and gamma-glutamyl-lysine isodipeptide bonds, which are formed by the action of transglutaminases (TGases). TGases are intercellularly localizing, Ca2+-dependent enzymes, which catalyze the formation of isopeptide bonds by transferring an amine on to glutaminyl residues, thereby cross-linking glutamine residues and lysine residues in substrate proteins. TGases influence numerous biological processes including blood coagulation, epidermal differentiation, seminal fluid coagulation, fertilization, cell differentiation and apoptosis. TGase4, also known as TGM4, TGP or hTGP, is a typical TGase that is specifically expressed in prostate tissue.
Function:
Associated with the mammalian reproductive process. Catalyzes the cross-linking of proteins and the conjugation of polyamines to specific proteins in the seminal tract.
Tissue Specificity:
Prostate.
Similarity:
Belongs to the transglutaminase superfamily. Transglutaminase family.
SWISS:
P49221
Gene ID:
7047
Database links:
Entrez Gene: 7047 Human
Omim: 600585 Human
SwissProt: P49221 Human
Unigene: 438265 Human
|
|