The signal sequence receptor (SSR) is a glycosylated endoplasmic reticulum (ER) membrane receptor associated with protein translocation across the ER membrane. The SSR consists of 2 subunits, a 34-kD glycoprotein encoded by this gene and a 22-kD glycoprotein. This gene generates several mRNA species as a result of complex alternative polyadenylation. This gene is unusual in that it utilizes arrays of polyA signal sequences that are mostly non-canonical. [provided by RefSeq, Jul 2008]
Function:
TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins. May be involved in the recycling of the translocation apparatus after completion of the translocation process or may function as a membrane-bound chaperone facilitating folding of translocated proteins.
Subcellular Location:
Endoplasmic reticulum membrane.
Similarity:
Belongs to the TRAP-alpha family.
SWISS:
P43307
Gene ID:
6745
Database links:
Entrez Gene: 6745 Human
Entrez Gene: 107513 Mouse
Entrez Gene: 361233 Rat
Omim: 600868 Human
SwissProt: P43307 Human
SwissProt: Q9CY50 Mouse
SwissProt: Q7TPJ0 Rat
Unigene: 114033 Human
Unigene: 426670 Mouse
Unigene: 490298 Mouse
Unigene: 123918 Rat
|
|
