Rabbit Anti-TRAPPC2 antibody

Home > Product > Antibody > Rabbit Anti-TRAPPC2 antibody

hYP38334; MBP 1 interacting protein 2A; MBP-1-interacting protein 2A; MIP 2A; MIP-2A; MIP2A; SEDL; Sedlin; SEDLP; SEDT; Spondyloepiphyseal dysplasia tarda protein; Spondyloepiphyseal dysplasia, late; TPC2A_HUMAN; Trafficking protein particle

Cat:

SL16583R

Species Reactivity：

(predicted: Human,Mouse,Rat,Chicken,Dog,Cow,Rabbit,Sheep,)

Immunogen：

KLH conjugated synthetic peptide derived from human TRAPPC2:71-140/140

Format：

Liquid

Storage instructions：

Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

ELISA=1:5000-10000IHC-P=1:100-500IHC-F=1:100-500ICC=1:100-500IF=1:100-500（Paraffin sections need to do antigen repair）not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

prev next

Unit:

Price: $228.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
Feedback Wall

The protein encoded by this gene is thought to be part of a large multi-subunit complex involved in the targeting and fusion of endoplasmic reticulum-to-Golgi transport vesicles with their acceptor compartment. In addition, the encoded protein can bind c-myc promoter-binding protein 1 and block its transcriptional repression capability. Mutations in this gene are a cause of spondyloepiphyseal dysplasia tarda (SEDT). A processed pseudogene of this gene is located on chromosome 19, and other pseudogenes are found on chromosomes 8 and Y. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2010]

Function:
Prevents MBP1-mediated transcriptional repression and antagonizes MBP1-mediated cell death. May play a role in vesicular transport from endoplasmic reticulum to Golgi.

Subcellular Location:
Cytoplasm > perinuclear region. Endoplasmic reticulum. Golgi apparatus. Localized in perinuclear granular structures.

Tissue Specificity:
Widely expressed.

DISEASE:
Defects in TRAPPC2 are the cause of spondyloepiphyseal dysplasia tarda (SEDT) [MIM:313400]. SEDT is an X-linked recessive disorder of endochondral bone formation.

Similarity:
Belongs to the TRAPP small subunits family. Sedlin subfamily.

SWISS:
O14582

Gene ID:
6399

Database links:

Entrez Gene: 6399 Human

Entrez Gene: 66050 Mouse

Entrez Gene: 66226 Mouse

Entrez Gene: 501550 Rat

Omim: 300202 Human

SwissProt: O14582 Human

SwissProt: P0DI81 Human

SwissProt: Q9CQP2 Mouse

Unigene: 592238 Human

Unigene: 622292 Human

Unigene: 279752 Mouse

Unigene: 35693 Mouse

Product Feedback Wall