Chromosome 1 is the largest human chromosome spanning about 260 million base pairs and making up 8% of the human genome. There are about 3,000 genes on chromosome 1, and considering the great number of genes there are also a large number of diseases associated with chromosome 1. Notably, the rare aging disease Hutchinson-Gilford progeria is associated with the LMNA gene which encodes lamin A. When defective, the LMNA gene product can build up in the nucleus and cause characteristic nuclear blebs. The mechanism of rapidly enhanced aging is unclear and is a topic of continuing exploration. The MUTYH gene is located on chromosome 1 and is partially responsible for familial adenomatous polyposis. Stickler syndrome, Parkinsons, Gaucher disease and Usher syndrome are also associated with chromosome 1. A breakpoint has been identified in 1q which disrupts the DISC1 gene and is linked to schizophrenia. Aberrations in chromosome 1 are found in a variety of cancers including head and neck cancer, malignant melanoma and multiple myeloma. The C1orf32 gene product has been provisionally designated C1orf32 pending further characterization.
Function:
May be involved in lipid homeostasis and ER stress pathways.
Subcellular Location:
Membrane.
Similarity:
Belongs to the immunoglobulin superfamily. LISCH7 family.
Contains 1 Ig-like SLVtype (immunoglobulin-like) domain.
SWISS:
Q71H61
Gene ID:
387597
Database links:
Entrez Gene: 387597 Human
SwissProt: Q71H61 Human
Unigene: 444835 Human
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