This locus encodes an inositol monophosphatase. The encoded protein catalyzes the dephosphoylration of inositol monophosphate and plays an important role in phosphatidylinositol signaling. This locus may be associated with susceptibility to bipolar disorder. [provided by RefSeq, Jan 2011]
Function:
Can use myo-inositol monophosphates, scylloinositol 1,4-diphosphate, glucose-1-phosphate, beta-glycerophosphate, and 2'-AMP as substrates. Has been implicated as the pharmacological target for lithium Li(+) action in brain.
Similarity:
Belongs to the inositol monophosphatase family.
SWISS:
O14732
Gene ID:
3613
Database links:
Entrez Gene: 3613 Human
Entrez Gene: 114663 Mouse
Entrez Gene: 282636 Rat
Omim: 605922 Human
SwissProt: O14732 Human
SwissProt: Q91UZ5 Mouse
SwissProt: Q8CIN7 Rat
Unigene: 723890 Human
Unigene: 726124 Human
Unigene: 34079 Mouse
Unigene: 441590 Mouse
Unigene: 856 Rat
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