This gene is a member of the inhibitor of growth (ING) family. Members of the ING family associate with and modulate the activity of histone acetyltransferase (HAT) and histone deacetylase (HDAC) complexes and function in DNA repair and apoptosis. [provided by RefSeq, Jul 2008]
Function:
Seems to be involved in p53/TP53 activation and p53/TP53-dependent apoptotic pathways, probably by enhancing acetylation of p53/TP53. Component of a mSin3A-like corepressor complex, which is probably involved in deacetylation of nucleosomal histones. ING2 activity seems to be modulated by binding to phosphoinositides (PtdInsPs).
Subcellular Location:
Nucleus. Predominantly nuclear. Localized to chromatin and nuclear matrix. Upon reduced PtdIns(5)P levels seems to be released from chromatin and, at least partially, translocated to the cytoplasm.
Tissue Specificity:
Widely expressed. Higher expressed in colon-cancer tumor than in normal colon tissues.
Similarity:
Belongs to the ING family.
Contains 1 PHD-type zinc finger.
SWISS:
Q9H160
Gene ID:
3622
Database links:
Entrez Gene: 3622 Human
Entrez Gene: 69260 Mouse
Entrez Gene: 290744 Rat
Omim: 604215 Human
SwissProt: Q9H160 Human
SwissProt: Q9ESK4 Mouse
Unigene: 107153 Human
Unigene: 430733 Mouse
Unigene: 20482 Rat
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