Rabbit Anti-Periaxin antibody

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PRX; CMT4F; KIAA1620; Periaxin; PRAX_MOUSE; Prx; L-Periaxin.

Cat:

SL10723R

Species Reactivity：

(predicted: Mouse,Rat,Dog,Pig,)

Immunogen：

KLH conjugated synthetic peptide derived from mouse Periaxin:1301-1391/1391

Format：

Liquid

Storage instructions：

Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

WB=1:500-2000ELISA=1:5000-10000IHC-P=1:100-500IHC-F=1:100-500ICC=1:100-500IF=1:100-500（Paraffin sections need to do antigen repair）not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

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Unit:

Price: $228.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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This gene encodes a protein involved in peripheral nerve myelin upkeep. The encoded protein contains 2 PDZ domains which were named after PSD95 (post synaptic density protein), DlgA (Drosophila disc large tumor suppressor), and ZO1 (a mammalian tight junction protein). Two alternatively spliced transcript variants have been described for this gene which encode different protein isoforms and which are targeted differently in the Schwann cell. Mutations in this gene cause Charcot-Marie-Tooth neuoropathy, type 4F and Dejerine-Sottas neuropathy. [provided by RefSeq, Jul 2008]

Function:
Seems to be required for maintenance of peripheral nerve myelin sheath. May have a role in axon-glial interactions, possibly by interacting with the cytoplasmic domains of integral membrane proteins such as myelin-associated glycoprotein in the periaxonal regions of the Schwann cell plasma membrane. May have a role in the early phases of myelin deposition.

Subunit:
Interacts with SCN10A. Found in a complex with SCN10A.

Subcellular Location:
Nucleus.Isoform 1: Cell membrane. Isoform 2: Cytoplasm.

Tissue Specificity:
Isoform 1 and isoform 2 are found in sciatic nerve and Schwann cells.

DISEASE:
Defects in PRX are a cause of Dejerine-Sottas syndrome (DSS) [MIM:145900]; also known as Dejerine-Sottas neuropathy (DSN) or hereditary motor and sensory neuropathy III (HMSN3). DSS is a severe degenerating neuropathy of the demyelinating Charcot-Marie-Tooth disease category, with onset by age 2 years. DSS is characterized by motor and sensory neuropathy with very slow nerve conduction velocities, increased cerebrospinal fluid protein concentrations, hypertrophic nerve changes, delayed age of walking as well as areflexia. There are both autosomal dominant and autosomal recessive forms of Dejerine-Sottas syndrome.

Similarity:
Belongs to the periaxin family. Contains 1 PDZ (DHR) domain.

SWISS:
O55103

Gene ID:
19153

Database links:
Entrez Gene: 57716 Human

Entrez Gene: 19153 Mouse

Entrez Gene: 78960 Rat

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