The protein encoded by this gene is similar to ING1, a tumor suppressor protein that can interact with TP53, inhibit cell growth, and induce apoptosis. This protein contains a PHD-finger, which is a common motif in proteins involved in chromatin remodeling. This protein can bind TP53 and EP300/p300, a component of the histone acetyl transferase complex, suggesting its involvement in TP53-dependent regulatory pathway. [provided by RefSeq, Jul 2008]
Function:
Component of the HBO1 complex which has a histone H4-specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo. Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity. Through chromatin acetylation it may regulate DNA replication and may function as a transcriptional coactivator.
Subcellular Location:
Nucleus.
Similarity:
Belongs to the ING family.
Contains 1 PHD-type zinc finger.
SWISS:
Q8WYH8
Gene ID:
84289
Database links:
Entrez Gene: 84289 Human
Entrez Gene: 66262 Mouse
Entrez Gene: 363292 Rat
Omim: 608525 Human
SwissProt: Q8WYH8 Human
SwissProt: Q9D8Y8 Mouse
Unigene: 529172 Human
Unigene: 12865 Mouse
Unigene: 214030 Rat
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