Methylation is an important reaction in the metabolism of many drugs, other xenobiotics and endogenous molecules. A methyltransferase is a type of transferase enzyme that transfers a methyl group from a donor to an acceptor. INMT (indolethylamine N-methyltransferase), also known as Temt or aromatic alkylamine N-methyltransferase, is a 264 amino acid protein belonging to the NNMT/PNMT/TEMT family. Localized to the cytoplasm, INMT catalyzes the N-methylation of tryptamine and structurally related compounds. Existing as a monomer, INMT may have a role in the in vivo synthesis of psychoactive compounds or neurotoxins. The gene encoding INMT maps to human chromosome 7p14.3 and mouse chromosome 6 B3.
Function:
Catalyzes the N-methylation of tryptamine and structurally related compounds.
Subcellular Location:
Cytoplasm.
Tissue Specificity:
Widely expressed. The highest levels were in thyroid, adrenal gland, adult and fetal lung. Intermediate levels in heart, placenta, skeletal muscle, testis, small intestine, pancreas, stomach, spinal cord, lymph node and trachea. Very low levels in adult and fetal kidney and liver, in adult spleen, thymus, ovary, colon and bone marrow. Not expressed in peripheral blood leukocytes and brain.
Similarity:
Belongs to the NNMT/PNMT/TEMT family.
SWISS:
O95050
Gene ID:
11185
Database links:
Entrez Gene: 11185 Human
Omim: 604854 Human
SwissProt: O95050 Human
Unigene: 632629 Human
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