The INO80 complex contributes to a wide variety of chromatin-dependent nuclear transactions, including transcription, DNA repair and DNA replication. Evolutionarily conserved from yeast to human, theINO80 complex belongs to a subfamily of the ATP-dependent chromatin remodelers and is characterized by a split ATPase domain in the core ATPase subunit. ATP-dependent chromatin remodeling complexes contain ATPases of the Swi/Snf superfamily and alter DNA accessibility of chromatin in an ATP-dependent manner. INO80D (INO80 complex subunit D), is an 878 amino acid protein that is a component of the chromatin-remodeling INO80 complex.
Function:
This protein is a component of the chromatin-remodeling INO80 complex, which is at least composed of ACTL6A, ACTR5, ACTR8, RVBL1, RVBL2, INO80, INO80B, INO80C, INO80D and INO80E.
Subunit:
Component of the chromatin remodeling INO80 complex; specifically part of a complex module associated with the N-terminus of INO80. {ECO:0000269|PubMed:16230350, ECO:0000269|PubMed:18922472, ECO:0000269|PubMed:21303910}.
Similarity:
Belongs to the INO80D family. {ECO:0000305}.
SWISS:
Q53TQ3
Gene ID:
54891
Database links:
Entrez Gene: 54891 Human
Entrez Gene: 227195 Mouse
SwissProt: Q53TQ3 Human
SwissProt: Q66JY2 Mouse
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