The inositol polyphosphate 4-phosphatases selectively remove the phosphate from the 4-position of various phosphatidylinositols, which generate second messengers in response to extracellular signals. Both the type I and type II 4-phosphatases catalyze the hydrolysis of phosphatidylinositol 3,4-bisphosphate, inositol 1,3,4-trisphosphate, and inositol 3,4-bisphosphate. Type I and type II 4-phosphatases are both alternatively spliced into two isoforms, a and b, which have been detected in human platelets, rat brain, heart, skeletal muscle and spleen; and all isoforms contain a conserved motif CKSAKDRT, which contains the active site consensus sequence SLCX5-R. Both type I and II 4-phosphatases are thought to regulate the level of intracellular calcium by acting as signal terminating enzymes.
Function:
Catalyzes the hydrolysis of the 4-position phosphate of phosphatidylinositol 3,4-bisphosphate, inositol 1,3,4-trisphosphate and inositol 3,4-bisphosphate.
Tissue Specificity:
Isoform 1 is expressed in the platelets, MEG-01 megakaryocytes and Jurkat T-cells. Isoform 2 is expressed in the brain.
Similarity:
Belongs to the inositol-3,4-bisphosphate 4-phosphatase family.
Contains 1 C2 domain.
SWISS:
Q96PE3
Gene ID:
3631
Database links:
Entrez Gene: 3631 Human
Entrez Gene: 26936 Mouse
Entrez Gene: 100233232 Pig
Entrez Gene: 80849 Rat
Entrez Gene: 734645 Xenopus laevis
Omim: 600916 Human
SwissProt: Q96PE3 Human
SwissProt: Q9EPW0 Mouse
SwissProt: Q62784 Rat
Unigene: 469386 Human
Unigene: 5294 Mouse
Unigene: 11215 Rat
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