INSL4 encodes the insulin-like 4 protein, a member of the insulin superfamily. INSL4 encodes a precursor that undergoes post-translational cleavage to produce 3 polypeptide chains, A-C, that form tertiary structures composed of either all three chains, or just the A and B chains. Expression of INSL4 products occurs within the early placental cytotrophoblast and syncytiotrophoblast. [provided by RefSeq, Jul 2008]
Function:
May play an important role in trophoblast development and in the regulation of bone formation.
Subcellular Location:
Secreted.
Tissue Specificity:
Expressed in placenta, uterus and in fetal perichondrium. Expression levels were increased in both early placentas and molar pregnancies and were reduced in choriocarcinoma cells.
Similarity:
Belongs to the insulin family.
SWISS:
Q14641
Gene ID:
3641
Database links:
Entrez Gene: 3641 Human
Omim: 600910 Human
SwissProt: Q14641 Human
Unigene: 418506 Human
|
|