Importins, including IPO11, are a members of the karyopherin/importin-beta family of transport receptors (see KPNB1; 602738) that mediate nucleocytoplasmic transport of protein and RNA cargoes (Plafker and Macara, 2000 [PubMed 11032817]).[supplied by OMIM, Sep 2008]
Function:
Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity). Mediates the nuclear import of UBE2E3, and of RPL12.
Subcellular Location:
Cytoplasm. Nucleus.
Similarity:
Belongs to the importin beta family.
Contains 15 HEAT repeats.
Contains 1 importin N-terminal domain.
SWISS:
Q9UI26
Gene ID:
51194
Database links:
Entrez Gene: 51194 Human
Entrez Gene: 76582 Mouse
Entrez Gene: 62056 Rat
Omim: 610889 Human
SwissProt: Q9UI26 Human
SwissProt: Q8K2V6 Mouse
Unigene: 482269 Human
Unigene: 132208 Mouse
Unigene: 482687 Mouse
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