The protein encoded by this gene is a member of the kelch family of proteins, which is characterized by a 50 amino acid repeat which interacts with actin. Transcript variants have been described but their full-length nature has not been determined. [provided by RefSeq, Jul 2008]
Function:
Intracisternal A particle promoted polypeptide (IPP) is a member of the kelch family of proteins, characterized by a 50 amino acid repeat which interacts with actin. The kelch domain of IPP consists of six C terminal tandem arranged repeats. IPP may play a role in organizing the actin cytoskeleton. IPP also contains an N terminal POZ protein protein interaction domain. The POZ domain (also called BTB domain) is present near the N terminus of a fraction of zinc finger proteins and in proteins that contain the pfam01344 motif such as kelch and pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co repressor complexes including N-coR and SMRT.
Subcellular Location:
Cytoplasm, cytoskeleton.
Similarity:
Contains 1 BTB (POZ) domain. {ECO:0000255|PROSITE-ProRule:PRU00037}.
Contains 6 Kelch repeats. {ECO:0000305}.
SWISS:
Q9Y573
Gene ID:
3652
Database links:
Entrez Gene: 3652 Human
Entrez Gene: 785293 Cow
Entrez Gene: 16351 Mouse
Entrez Gene: 298439 Rat
Omim: 147485 Human
SwissProt: Q9Y573 Human
SwissProt: P28575 Mouse
Unigene: 699548 Human
Unigene: 229516 Rat
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