The protein encoded by this gene is a kinase that phosphorylates position 2 of inositol-1,3,4,5,6-pentakisphosphate to form inositol-1,2,3,4,5,6-hexakisphosphate (InsP6). InsP6 has a variety of functions, including stimulation of DNA repair, endocytosis, and mRNA export. [provided by RefSeq, Nov 2010]
Function:
Phosphorylates Ins(1,3,4,5,6)P5 at position 2 to form Ins(1,2,3,4,5,6)P6 (InsP6 or phytate). InsP6 is involved in many processes such as mRNA export, non-homologous end-joining, endocytosis, ion channel regulation. It also protects cells from TNF-alpha-induced apoptosis.
Subcellular Location:
Cytoplasm. Nucleus.
Tissue Specificity:
Ubiquitously expressed, with high expression in heart, brain, testis and placenta.
Similarity:
Belongs to the IPK1 type 2 family.
SWISS:
Q9H8X2
Gene ID:
64768
Database links:
Entrez Gene: 64768 Human
Entrez Gene: 75678 Mouse
Entrez Gene: 301368 Rat
SwissProt: Q9H8X2 Human
SwissProt: Q6P1C1 Mouse
SwissProt: Q5PXE9 Rat
Unigene: 459896 Human
Unigene: 713775 Human
Unigene: 390586 Mouse
Unigene: 211702 Rat
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