Rabbit Anti-Nephrocystin 5 antibody

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IQ motif containing B1; IQ calmodulin binding motif containing protein 1; IQCB1; Nephrocystin 5; NPHP5; IQCB1_HUMAN; Nephrocystin-5 Nephrocystin5.

Cat:

SL16688R

Species Reactivity：

(predicted: Human,Mouse,Rat,Dog,Pig,Horse,Rabbit,)

Immunogen：

KLH conjugated synthetic peptide derived from human Nephrocystin 5:351-450/598

Format：

Liquid

Storage instructions：

Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

ELISA=1:5000-10000IHC-P=1:100-500IHC-F=1:100-500ICC=1:100-500IF=1:100-500（Paraffin sections need to do antigen repair）not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

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Unit:

Price: $228.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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This gene encodes a nephrocystin protein that interacts with calmodulin and the retinitis pigmentosa GTPase regulator protein. The encoded protein has a central coiled-coil region and two calmodulin-binding IQ domains. It is localized to the primary cilia of renal epithelial cells and connecting cilia of photoreceptor cells. The protein is thought to play a role in ciliary function. Defects in this gene result in Senior-Loken syndrome type 5. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2009]

Function:
Interacts with calmodulin.

Subcellular Location:
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:21565611}. Note=Localization to the centrosome depends on the interaction with CEP290.

Tissue Specificity:
Ubiquitously expressed in fetal and adult tissues. Localized to the outer segments and connecting cilia of photoreceptor cells. Up-regulated in a number of primary colorectal and gastric tumors. {ECO:0000269|PubMed:15723066, ECO:0000269|PubMed:16322217}.

DISEASE:
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:21565611}. Note=Localization to the centrosome depends on the interaction with CEP290.

Similarity:
Contains 4 IQ domains.

SWISS:
Q15051

Gene ID:
9657

Database links:

Entrez Gene: 9657 Human

Omim: 609237 Human

SwissProt: Q15051 Human

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