Interferon consensus sequence-binding protein (ICSBP) is a transcription factor of the interferon (IFN) regulatory factor (IRF) family. Proteins of this family are composed of a conserved DNA-binding domain in the N-terminal region and a divergent SLCterminal region that serves as the regulatory domain. The IRF family proteins bind to the IFN-stimulated response element (ISRE) and regulate expression of genes stimulated by type I IFNs, namely IFN-alpha and IFN-beta. IRF family proteins also control expression of IFN-alpha and IFN-beta-regulated genes that are induced by viral infection. [provided by RefSeq, Jul 2008]
Function:
Specifically binds to the upstream regulatory region of type I IFN and IFN-inducible MHC class I genes (the interferon consensus sequence (ICS)). Plays a negative regulatory role in cells of the immune system.
Subcellular Location:
Nucleus.
Tissue Specificity:
Predominantly in lymphoid tissues.
Post-translational modifications:
Ubiquitinated. Ubiquitination by TRIM21 in macrophages, a process that is strongly increased upon interferon gamma stimulation, leds to the enhanced transcriptional activity of target cytokine genes.
Similarity:
Belongs to the IRF family.
Contains 1 IRF tryptophan pentad repeat DNA-binding domain.
SWISS:
Q02556
Gene ID:
3394
Database links:
Entrez Gene: 3394 Human
Entrez Gene: 396385 Chicken
Entrez Gene: 454294 Chimpanzee
Entrez Gene: 100770390 Chinese Hamster
Entrez Gene: 614909 Cow
Entrez Gene: 489673 Dog
Entrez Gene: 101152979 Gorilla
Entrez Gene: 15900 Mouse
Entrez Gene: 100173775 Orangutan
Entrez Gene: 396645 Pig
Entrez Gene: 100350620 Rabbit
Entrez Gene: 292060 Rat
Entrez Gene: 693933 Rhesus monkey
Omim: 601565 Human
SwissProt: Q90871 Chicken
SwissProt: Q02556 Human
SwissProt: P23611 Mouse
Unigene: 137427 Human
Unigene: 334861 Mouse
Unigene: 228738 Rat
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